Mycophenolate myopathy following liver transplantation: Case report

Authors

DOI:

https://doi.org/10.59093/27112330.124

Keywords:

myotoxicity, hepatic transplantation, mycophenolic acid

Abstract

Drug-induced myopathies are a relatively common cause of acute muscle weakness. In many cases, symptoms begin shortly after initiating the causative medication; however, diagnosis can be challenging due to polypharmacy or the initial association of symptoms with other pathologies. This can lead to a delay in withdrawing the medication, which is essential for treatment. We present the case of a 62-year-old patient with a history of hepatocellular carcinoma who developed acute muscle weakness in the early postoperative period following liver transplantation. An exceptional association with mycophenolate-induced myopathy was documented. Upon discontinuation of this medication, the patient regained full muscle strength, confirming the diagnosis. In fact, this case is the second reported in the medical literature of mycophenolate-induced myopathy.

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Author Biographies

Kevin Aníbal Lloreda-Aranzazú, Pontificia Universidad Javeriana, Clínica Imbanaco

Médico, Residente de Medicina de Urgencias, Pontificia Universidad Javeriana, Clínica Imbanaco. Cali, Colombia.

Álvaro Andrés Montenegro-Apráez, Clínica Imbanaco, Universidad Javeriana

Médico, Especialista en Cuidados Intensivos, Clínica Imbanaco. Docente del programa de Medicina de Urgencias, Universidad Javeriana. Cali, Colombia.

Diego Mauricio Gómez-Ramírez, Clínica Imbanaco

Médico, Especialista en Gastroenterología y Hepatología. Grupo de Trasplante Hepático, Clínica Imbanaco. Cali, Colombia.

Mauricio Aragón-Delgado, Clínica Imbanaco, Universidad Javeriana

Médico, Especialista en Medicina Interna, Clínica Imbanaco. Docente, Programa de Medicina de Urgencias, Universidad Javeriana. Cali, Colombia.

Lady Viviana Acosta-Castillo, Universidad Libre seccional Cali

Médica, Residente de Medicina Interna, Universidad Libre seccional Cali. Cali, Colombia.

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Published

2024-09-03

How to Cite

Lloreda-Aranzazú, K. A., Montenegro-Apráez, Álvaro A., Gómez-Ramírez, D. M., Aragón-Delgado, M., & Acosta-Castillo, L. V. (2024). Mycophenolate myopathy following liver transplantation: Case report. Hepatología, 5(3), 230–237. https://doi.org/10.59093/27112330.124
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