Chylous ascites as a manifestation of hepatocellular carcinoma: A case report

Authors

DOI:

https://doi.org/10.59093/27112330.125

Keywords:

chylous ascites, carcinoma, hepatocellular, transcatheter arterial chemoembolization, case report.

Abstract

Chylous ascites is a rare and infrequent form of ascites resulting from the leakage of lipid-rich lymphatic fluid into the peritoneal cavity, most often secondary to trauma or obstruction. However, it can also be of infectious, cardiogenic, cirrhotic, or neoplastic origin, with the latter accounting for one-third of cases. The diagnosis is based on the characteristics of the ascitic fluid (AF), described as "milky", with triglyceride levels generally greater than 200 mg/dL. Management consists of treating the underlying disease causing it, along with dietary modifications and diuretics. In this article, we present a case of a patient with a history of alcohol-related liver disease who was admitted to the emergency department with a second episode of ascitic edematous decompensation and tense ascites, this time with evidence of turbid and chylous ascitic fluid, with triglyceride levels of 201 mg/dL. Subsequent evaluation led to a diagnosis of hepatocellular carcinoma. A low-fat diet supplemented with medium-chain triglycerides was prescribed, resulting in a decrease in AF triglyceride levels below 100 mg/dL and favorable clinical outcomes. Given the patient's ineligibility for transplantation, transarterial chemoembolization (TACE) was employed as a palliative treatment for the hepatocellular carcinoma.

Downloads

Download data is not yet available.

Author Biographies

Diego Andrés Hernández-Dinas, Clínica Imbanaco

Médico, Especialista en Medicina Interna, Clínica Imbanaco. Cali, Colombia. Fellow de Gastroenterología, Universidad de la Sabana. Chía, Cundinamarca.

Manuel Alonso Ardila-Báez, Fundación Clínica Shaio, Universidad de la Sabana

Médico, Especialista en Medicina Interna y Epidemiología, Fundación Clínica Shaio. Bogotá D.C., Colombia. Fellow de Gastroenterología, Universidad de la Sabana. Chía, Cundinamarca.

María Camila Hernández-Suárez, Fundación Universitaria Juan N. Corpas

Médica, Residente de Medicina Interna, Fundación Universitaria Juan N. Corpas. Bogotá D.C., Colombia.

Francisco Andrés Petano-Romero, Fundación Clínica Shaio, Universidad de la Sabana

Médico, Especialista en Cirugía General, Fundación Clínica Shaio. Bogotá D.C., Colombia. Fellow de Gastroenterología, Universidad de la Sabana. Chía, Cundinamarca.

Hermes José Cuel-López, Universidad de la Sabana

Médico, Especialista en Medicina Interna. Fellow de Gastroenterología, Universidad de la Sabana. Chía, Cundinamarca.

Omar Yesid Martínez-Casas, Fundación Clínica Shaio, LiverScan SAS

Médico, Especialista en Medicina Interna y Epidemiología, Especialista en Hepatología. Fundación Clínica Shaio, LiverScan SAS. Bogotá D.C., Colombia.

References

Sobrino PS, Cañete BLR, Trastoy OD, Temprano NV, Murcia CM, Marta SE. Manejo de la ascitis quilosa y revisión de la literatura. Nutr Clín Diet Hosp 2022;42:126-33. 2022; 42(1):126-133. https://doi.org/10.12873/421diaz.

Press OW, Press NO, Kaufman SD. Evaluation and management of chylous ascites. Ann Intern Med 1982;96:358-364. https://doi.org/10.7326/0003-4819-96-3-358.

Castellote J, Porta F. Chylous ascites secondary to liver cirrhosis. Rev Esp Enferm Dig 1994;86:912-914.

Laterre PF, Dugernier T, Reynaert MS. Chylous ascites: diagnosis, causes and treatment. Acta Gastroenterol Belg 2000;63:260-263.

Huang Q, Jiang ZW, Jiang J, Li N, Li JS. Chylous ascites: treated with total parenteral nutrition and somatostatin. World J Gastroenterol 2004;10:2588-2591. https://doi.org/10.3748/wjg.v10.i17.2588.

Piña-Pedraza JP, Álvarez-Avalos L, Vargas-Espinosa JM, Salcedo-Gómez A, Carranza-Madrigal J. Ascitis quilosa secundaria a cirrosis hepática. Rev Gastroenterol Mex 2015;80:285-287. https://doi.org/10.1016/j.rgmx.2015.04.005

Jiménez CE. Ascitis quilosa: presentación de un caso y revisión de la fisiopatología. Rev Colomb Cir 2004;19:76-84.

Dougan M, Anderson M, Abramson JS, Fitzpatrick MJ. Case 14-2022: A 57-year-old man with chylous ascites. N Engl J Med 2022;386:1923-1930. https://doi.org/10.1056/NEJMcpc2115856.

Almakdisi T, Massoud S, Makdisi G. Lymphomas and chylous ascites: Review of the literature. Oncologist 2005;10:632-635. https://doi.org/10.1634/theoncologist.10-8-632.

Bhardwaj R, Vaziri H, Gautam A, Ballesteros E, Karimeddini D, Wu GY. Chylous ascites: A review of pathogenesis, diagnosis and treatment. J Clin Transl Hepatol 2018 Mar 28;6:105-113. https://doi.org/10.14218/JCTH.2017.00035.

Sultan S, Pauwels A, Poupon R, Lévy VG. Chylous ascites in adults: Etiological, therapeutic and prognostic aspects. Apropos of 35 cases. Ann Gastroenterol Hepatol 1990;26:187-191.

Gómez-Soto FM, Marcos-Sánchez F, Franco-Moreno AI, Viana-Alonso A, Muñoz-Ruiz AI, Duran Pérez-Navarro A. Ascitis quilosa como forma de presentación de un hepatocarcinoma. Gastroenterol Hepatol 2003;26:276-277. https://doi.org/10.1016/s0210-5705(03)70356-2.

Sultan S, Pauwels A, Poupon R, Lévy VG. Chylous ascites in cirrhosis. Retrospective study of 20 cases. Gastroenterol Clin Biol 1990;14:842-847.

Singal AG, Llovet JM, Yarchoan M, Mehta N, Heimbach JK, Dawson LA, et al. AASLD Practice Guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma. Hepatology 2023;78:1922-1965. https://doi.org/10.1097/HEP.0000000000000466.

Marrero JA, Kulik LM, Sirlin CB, Zhu AX, Finn RS, Abecassis MM, et al. Diagnosis, staging, and management of hepatocellular carcinoma: 2018 Practice Guidance by the American Association for the Study of Liver Diseases. Hepatology 2018;68:723-750. https://doi.org/10.1002/hep.29913.

Lizaola B, Bonder A, Trivedi HD, Tapper EB, Cardenas A. Review article: the diagnostic approach and current management of chylous ascites. Aliment Pharmacol Ther 2017;46:816-824. https://doi.org/10.1111/apt.14284.

Yildirim AE, Altun R, Can S, Öcal S, Akbas E, Korkmaz M, et al. Idiopathic chylous ascites treated with total parenteral nutrition and octreotide: a case report and review of the literature. Eur J Gastroenterol Hepatol 2011;23:961-964. https://doi.org/10.1097/MEG.0b013e328349aa2d.

Titó L, Ginès P, Arroyo V, Planas R, Panés J, Rimola A, Llach J, Humbert P, Badalamenti S, Jiménez W, et al. Total paracentesis associated with intravenous albumin management of patients with cirrhosis and ascites. Gastroenterology 1990;98:146-151. https://doi.org/10.1016/0016-5085(90)91303-n.

Huang Y, Gloviczki P, Duncan AA, Fleming MD, Driscoll DJ, Kalra M, Oderich GS, Bower TC. Management of refractory chylous ascites with peritoneovenous shunts. J Vasc Surg Venous Lymphat Disord 2017;5:538-546. https://doi.org/10.1016/j.jvsv.2017.03.011.

Published

2025-01-02

How to Cite

Hernández-Dinas, D. A., Ardila-Báez, M. A., Hernández-Suárez, M. C., Petano-Romero, F. A., Cuel-López, H. J., & Martínez-Casas, O. Y. (2025). Chylous ascites as a manifestation of hepatocellular carcinoma: A case report. Hepatología, 6(1), 55–62. https://doi.org/10.59093/27112330.125

Issue

Section

Case reports
QR Code
Crossref Cited-by logo
Article metrics
Abstract views
Galley vies
PDF Views
HTML views
Other views

Some similar items: