Falciform colangiopathy as a simulator of primary sclerosing colangitis

Authors

DOI:

https://doi.org/10.59093/27112330.129

Keywords:

hepatopathy, sickle cell disease, sickle cell hepatopathy, cholangiopathy, sclerosing cholangitis.

Abstract

Sickle cell disease (SCD) presents a wide spectrum of clinical manifestations, including liver disease. Hepatopathy in SCD ranges from viral hepatitis and iron overload to cirrhosis and chronic ischemic cholangiopathy, the latter being a poorly recognized entity. We describe a case of chronic ischemic cholangiopathy secondary to SCD in an 18-year-old female patient. Biochemical liver abnormalities were documented, along with imaging showing bile duct dilation and stenosis in the absence of secondary causes.

Downloads

Author Biographies

Vanessa López-Montoya, Universidad de Antioquia

Médica, Residente de Medicina Interna, Universidad de Antioquia. Medellín, Colombia.

Luis Germán Pulgarín-Ricardo, Hospital Universitario San Vicente Fundación

Médico, Especialista en Radiología, Hospital Universitario San Vicente Fundación. Medellín, Colombia.

Lina Paola Tovar-Díaz, Hospital Universitario San Vicente Fundación, Universidad de Antioquia

Médica, Especialista en Medicina Interna, Hospital Universitario San Vicente Fundación. Profesora, Departamento de Medicina Interna, Universidad de Antioquia. Medellín, Colombia. 

References

Theocharidou E, Suddle AR. The liver in sickle cell disease. Clin Liver Dis 2019;23:177-189. https://doi.org/10.1016/j.cld.2019.01.001.

Bauer TW, Moore GW, Hutchins GM. The liver in sickle cell disease. A clinicopathologic study of 70 patients. Am J Med 1980;69:833-837. https://doi.org/10.1016/0002-9343(80)90344-2.

Karlsen TH, Folseraas T, Thorburn D, Vesterhus M. Primary sclerosing cholangitis - a comprehensive review. J Hepatol 2017;67:1298-1323. https://doi.org/10.1016/j.jhep.2017.07.011.

Dyson JK, Beuers U, Jones DE, Lohse AW, Hudson M. Primary sclerosing cholangitis. Lancet Lond Engl 2018;391:2547–2559. https://doi.org/10.1016/S0140-6736(18)30977-8.

Alkhayyat M, Saleh MA, Zmaili M, Sanghi V, Singh T, Rouphael C, et al. Successful liver transplantation for acute sickle cell intrahepatic cholestasis: A case report and review of the literature. World J Hepatol 2020;12:108-115. https://doi.org/10.4254/wjh.v12.i3.108.

Praharaj DL, Anand AC. Sickle Hepatopathy. J Clin Exp Hepatol 2021;11:82-96. https://doi.org/10.1016/j.jceh.2020.06.001.

Issa H, Al-Haddad A, Al-Salem A. Sickle cell cholangiopathy: an endoscopic retrograde cholangiopancreatography evaluation. World J Gastroenterol 2009;15:5316-5320. https://doi.org/10.3748/wjg.15.5316.

Allali S, de Montalembert M, Brousse V, Heilbronner C, Taylor M, Brice J, et al. Hepatobiliary complications in children with sickle cell disease: A retrospective review of medical records from 616 patients. J Clin Med 2019;8:1416. https://doi.org/10.3390/jcm8091416.

Downloads

Published

2025-01-02

How to Cite

López-Montoya, V., Pulgarín-Ricardo, L. G., & Tovar-Díaz, L. P. (2025). Falciform colangiopathy as a simulator of primary sclerosing colangitis. Hepatología, 6(1), 63–67. https://doi.org/10.59093/27112330.129

Issue

Vol. 6 No. 1 (2025): January-April

Section

Case reports

License

Copyright (c) 2025 Authors retain all copyright and grant the Colombian Association of Hepatology a non-exclusive right to publish and disseminate their work.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Hepatología’s authorship policy is based on the criteria established by the International Committee of Medical Journal Editors (ICMJE) to credit a person for their work while assigning them responsibility for its publication.

QR Code
Crossref Cited-by logo
Article metrics
Abstract views
Galley vies
PDF Views
HTML views
Other views