Congestive liver disease, the hepatic consequences of a diseased heart
DOI:
https://doi.org/10.52784/27112330.146Keywords:
liver injury, liver disease, congestion, venous, central venous pressure, heart failure, cardiomyopathy, heart transplantation.Abstract
Congestive liver disease comprises the spectrum of manifestations secondary to liver injury as a consequence of hepatic venous congestion due to a disturbance in the hepatic venous outflow. The most frequent cause is right heart failure, which, due to an increase in central venous pressure, leads retrogradely to an increase in hepatic venous pressure, a decrease in liver inflow and a decrease in oxygen saturation, with sinusoidal congestion and characteristic compromise of zone 3 hepatocytes. Its presentation is usually subclinical in terms of liver manifestations, masked by the signs and symptoms of heart failure. The diagnosis includes the sum of serological, imaging and histologica findings, after exclusion of other entities involving liver injury. Treatment is based on the management of the underlying heart failure and the prognosis is as well dependent on the stage of the underlying heart disease. A literature search was carried out in order to create a review of this entity with updated concepts based on recent evidence.
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References
Hilscher M, Sanchez W. Congestive hepatopathy. Clin Liver Dis 2016;8:68-71. https://doi.org/https://doi.org/10.1002/cld.573.
El Hadi H, Di Vincenzo A, Vettor R, Rossato M. Relationship between Heart Disease and Liver Disease: A Two-Way Street. Cells 2020;9:567. https://doi.org/10.3390/cells9030567.
Xanthopoulos A, Starling RC, Kitai T, Triposkiadis F. Heart failure and liver disease: Cardiohepatic interactions. JACC Heart Fail 2019;7:87-97. https://doi.org/10.1016/j.jchf.2018.10.007.
Wells ML, Venkatesh SK. Congestive hepatopathy. Abdom Radiol (NY) 2018;43:2037-2051. https://doi.org/10.1007/s00261-017-1387-x.
Wells ML, Fenstad ER, Poterucha JT, Hough DM, Young PM, Araoz PA, et al. Imaging findings of congestive hepatopathy. RadioGraphics 2016;36:1024-1037. https://doi.org/10.1148/rg.2016150207.
Sundaram V, Fang JC. Gastrointestinal and Liver Issues in Heart Failure. Circulation 2016;133:1696-1703. https://doi.org/10.1161/circulationaha.115.020894.
Correale M, Tarantino N, Petrucci R, Tricarico L, Laonigro I, Di Biase M, et al. Liver disease and heart failure: Back and forth. Eur J Intern Med 2018;48:25-34. https://doi.org/10.1016/j.ejim.2017.10.016.
Pendyal A, Gelow JM. Cardiohepatic interactions: Implications for management in advanced heart failure. Heart Fail Clin 2016;12:349-361. https://doi.org/10.1016/j.hfc.2016.03.011.
Lightsey JM, Rockey DC. Current concepts in ischemic hepatitis. Curr Opin Gastroenterol 2017;33:158-163. https://doi.org/10.1097/mog.0000000000000355.
Lemmer A, VanWagner LB, Ganger D. Assessment of advanced liver fibrosis and the risk for hepatic decompensation in patients with congestive hepatopathy. Hepatology 2018;68:1633-1641. https://doi.org/10.1002/hep.30048.
Lemmer A, VanWagner L, Ganger D. Congestive hepatopathy: Differentiating congestion from fibrosis. Clin Liver Dis (Hoboken) 2017;10:139-143. https://doi.org/10.1002/cld.676.
Koehne-de Gonzalez AK, Lefkowitch JH. Heart disease and the liver: Pathologic evaluation. Gastroenterol Clin North Am 2017;46:421-435. https://doi.org/10.1016/j.gtc.2017.01.012.
Tapper EB, Sengupta N, Bonder A. The Incidence and outcomes of ischemic hepatitis: A systematic review with meta-analysis. Am J Med 2015;128:1314-1321. https://doi.org/10.1016/j.amjmed.2015.07.033.
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